Clinical Trials Ontario (CTO) is an independent, non-profit organization established with support from the Government of Ontario. Their mandate is to work collaboratively with the clinical trials community, the public, and various partners to attract clinical trial investment to Ontario. The streamlined ethics review system aims to decrease the time to getting clinical trials started by having ethics review completed by a single, qualified research ethics board performing the review for all sites involved in a study. All other required institutional approvals must also be obtained prior to the conduct of the study at Unity Health Toronto (e.g. Privacy, Clinical Ethics, etc). Each institution’s approval groups may have questions/concerns about the approved Provincial Initial Application (PIA) protocol that a study team will need to direct to the Provincial Lead PI and the Board of Record.
*Note: When St. Michael’s Hospital is the Provincial Applicant site, the research team should immediately create the Centre Initial Application for St. Michael’s Hospital – right after creating the Provincial Initial Application.
The Unity Health Toronto Institutional Approval Form replaces all previous study impact forms including individual site-specific forms. This form must be submitted for all new Clinical Trials Ontario (CTO) submissions.
Please be sure to re-visit this page often to download the form when starting new studies as the form is frequently updated.
For questions regarding CTO, please contact Elizabeth Huggins Elizabeth.Huggins@unityhealth.to