Pre-Clinical Imaging

The pre-clinical imaging facility offers imaging technology for the research community by providing access to in vivo imaging equipment.

Online scheduling is available only to those individuals who have received training on equipment. Review the Imaging guideline on how to receive training. 

Acquisition Systems:

In Vivo Imaging Equipment:

Whole animal photo-acoustic imaging of anesthetized mice. Capable of longitudinal studies done on the same animal.  Allows for the real time measurement of both deoxygenated and oxygenated hemoglobin without the requirement of labels. In addition, dyes (such as ICG) may used and spectrally unmixed from hemoglobin in post processing steps.
Heidleberg Spectralis (HRA+OCT)
Simultaneous fundus (retina, optic disc, macula, fovea, posterior pole) imaging and optical coherence tomography. Adapted for use on animals. Imaging Modalities: OCT, infrared, autoflourescence, fluorescein angiography, ICG angiography, red free photography

The Newton 7.0 FT500 is capable of both bioluminescence (2D and 3D tomography) as well as fluorescence imaging.

Designed for preclinical in vivo imaging of small animals with a fully automated heated stage and an integrated anesthesia system – allowing for up to 5 mice to be imaged simultaneously. (Also capable of ex vivo and in vitro applications.)

Camera – wide aperture (f/0.7) 16-bit cooled CCD camera

Fluorescence – 8 LED excitation channels, and 8 narrow bandpass emission filters for a wide array of fluorophores (420nm – 780nm).

Image of NEWTON 7.0

MILabs’ U-CT is extremely fast and offers ultra-high resolution at low X-ray doses enabling demanding multispecies 3D/4D in vivo applications, including dynamic contrast-enhanced (DCE) CT imaging. The system allows for dual-gated cardiac and respiratory imaging for freeze-frame acquisitions and features sensor-free respiratory gating for imaging up to four mice simultaneously and medium-sized animals.

  • Ultra-fast X-ray CT with a scan time of down to 5 seconds for mouse total body imaging
  • Fully integrated dynamic combined (dual gated) and independent cardiac and respiratory gating
  • Sensor-free, projection-based CT cardiac and respiratory gating of up to 4 mice simultaneously
  • Option to image up to 4 mice simultaneously in the CT
  • Standard trans axial field of view with a diameter of 75 mm and a scanning length of 220 mm
  • Medium Size Animal (MSA) imaging, e.g., for total body scanning of up to 5 Kg rabbits

Bio-monitoring and animal handling

  • Physiological monitoring unit of animals including ECG triggering, animal temperature regulation and respiration
  • Integrated mice and rat animal beds including heater pads and anesthesia cones
  • Live optical camera to monitor the animal during scanning
  • Special dedicated animal beds supporting the simultaneous scanning of up to 4 mice for high throughput imaging with CT
  • Ex vivo sample holders
  • Docking station for animal positioning, injection, and preparation prior to acquisition

Other general information

  • Fully integrated acquisition computer for CT system
  • Separate reconstruction workstation which can be accessed remotely from different computers
  • User-friendly touchscreen acquisition input and management console for CT
  • Export data formats: TIFF for reconstructed slices; NIFTI or DICOM for reconstructed 3D volume
  • Software license of post-processing image analysis software Imalytics and PMOD

Registration Form


uCT Image Analysis Software:

Licensed Software: Remote access can be booked on RFBMS

  • Tutorial videos 
  • 3D-visualization
  • Interactive segmentation
  • Analysis of preclinical image data sets
  • Supports data sets from several modalities such as CT, MRI, PET, SPECT, and optical imaging

Free software

  • Click here to download the software
  • Extensive and user-friendly artificial intelligence (machine and deep learning) segmentation tools
  • Various histogram-based segmentation techniques
  • Various quantitative analysis tools for materials analysis
  • Ease-of-use
  • Extensive selection of tutorial videos
  • Free webinars