Pre-Clinical Imaging

The pre-clinical imaging facility offers imaging technology for the research community by providing access to in vivo imaging equipment.

Online scheduling is available only to those individuals who have received training on equipment. Review the Imaging guideline on how to receive training. 


Acquisition Systems:

In Vivo Imaging Equipment:

Whole animal photo-acoustic imaging of anesthetized mice. Capable of longitudinal studies done on the same animal.  Allows for the real time measurement of both deoxygenated and oxygenated hemoglobin without the requirement of labels. In addition, dyes (such as ICG) may used and spectrally unmixed from hemoglobin in post processing steps.
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Heidleberg Spectralis (HRA+OCT)
Simultaneous fundus (retina, optic disc, macula, fovea, posterior pole) imaging and optical coherence tomography. Adapted for use on animals. Imaging Modalities: OCT, infrared, autoflourescence, fluorescein angiography, ICG angiography, red free photography
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The Newton 7.0 FT500 is capable of both bioluminescence (2D and 3D tomography) as well as fluorescence imaging.

Designed for preclinical in vivo imaging of small animals with a fully automated heated stage and an integrated anesthesia system – allowing for up to 5 mice to be imaged simultaneously. (Also capable of ex vivo and in vitro applications.)

Camera – wide aperture (f/0.7) 16-bit cooled CCD camera

Fluorescence – 8 LED excitation channels, and 8 narrow bandpass emission filters for a wide array of fluorophores (420nm – 780nm).

Image of NEWTON 7.0

MILabs’ U-CT is extremely fast and offers ultra-high resolution at low X-ray doses enabling demanding multispecies 3D/4D in vivo applications, including dynamic contrast-enhanced (DCE) CT imaging. The system allows for dual-gated cardiac and respiratory imaging for freeze-frame acquisitions and features sensor-free respiratory gating for imaging up to four mice simultaneously and medium-sized animals.

Specifications

  • Ultra-high resolution 2.4 µm
  • Dynamic contrast-enhanced (DCE) CT imaging
  • Dual-energy CT imaging
  • Ultra-low dose, down to < 2 mGy whole-body mouse

Registration Form

 


uCT Image Analysis Software:

Licensed Software: Remote access can be booked on RFBMS

  • Tutorial videos 
  • 3D-visualization
  • Interactive segmentation
  • Analysis of preclinical image data sets
  • Supports data sets from several modalities such as CT, MRI, PET, SPECT, and optical imaging

Free software

  • Click here to download the software
  • Extensive and user-friendly artificial intelligence (machine and deep learning) segmentation tools
  • Various histogram-based segmentation techniques
  • Various quantitative analysis tools for materials analysis
  • Ease-of-use
  • Extensive selection of tutorial videos
  • Free webinars